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30 , 31 Once PKD has been diagnosed, screening and regular monitoring for complications from chronic hemolysis should be initiated, since many complications, such as iron overload, can be asymptomatic

Furthermore, apoptosis is regulated by two main pathways, the death receptor pathway and the mitochondrial pathway, with ROS strongly implicated in the signal transduction of these pathways (Johar et al., 2015)

POAG has a clear genetic foundation, with heritability amongst twins ~0.95, and siblings of affected individuals having nearly an eight-fold increase risk of developing the disease