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PMID: 12459848 Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, et al

Formulas for acute diarrhea may only be used for a week, but herbs for chronic GI issues are usually given for one to three months

Discontinue use if irritation occurs and rinse with water

On the contrary, SAM/SAH was significantly decreased in NAM-supplemented NNMT overexpression mice