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DNA methylation potentially changes during development and in response to inflammation can shift microglia toward disease-associated phenotypes

While direct evidence for NGFs efficacy in tinnitus patients remains to be established, its established role in neuronal survival, synaptic plasticity, and emotional regulation, combined with emerging bioinformatic evidence of its involvement in tinnitus-related synaptic processes, provides a compelling rationale for further investigating the hypothesis that targeting the NGF/TrkA pathway could simultaneously ameliorate auditory perceptive distortions and the debilitating emotional symptoms that often accompany chronic tinnitus (Gross et al., 2023

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