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APN is a type II metalloproteinase that belongs to the M1 family (Luan and Xu, 2007)

doi: 10.3389/fphar.2024.1478170 Received 09 August 2024 Accepted 07 October 2024 Published 17 October 2024 Volume 15 - 2024 Edited by Nageswaran Sivalingam, RM Institute of Science and Technology, India Reviewed by Kusmardi Kusmardi, University of Indonesia, Indonesia Arumugam Suriyam Nagappan, University of Madras, India Updates Copyright 2024 Gan, Shi, Liu, Ding, Qiu and Luo

doi: 10.1007/s12035-017-0798-6 45

The impact of changed redoxin function on ferroptosis could also be based on secondary effects, e.g., the increase in superoxide formation upon loss of mitochondrial redoxins [90,91] or activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [92,93] , a major regulator of transcription of antioxidant and anti-ferroptotic enzymes [65]