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Among these, the , -unsaturated aldehyde 4-hydroxy-2-nonenal (4-HNE) and di-aldehyde malondialdehyde (MDA) are most studied (Fig

However, once they surpass their physiological concentrations, ROS subject cells to oxidative stress and viciously interact with cellular proteins, carbohydrates, nucleic acid, and lipids, resulting in DNA and protein damage and lipid peroxidation [24] (Fig

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