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Consumers should not use a high-dose supplement to delay medical assessment when symptoms are persistent or significant
Interactions with common perioperative and orthopedic drugs NSAIDs, corticosteroids, and anesthetic agents are uncharacterized, which matters precisely because orthopedic patients are frequently on those medications

Monick et al., 2003

This contrasts sharply with orthobiologic therapies like PRP and mesenchymal stem cell therapies, both of which have been evaluated in multiple randomized controlled trials and large observational studies