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Structural understanding of disease/drug resistance-related androgen receptor mutations through X-ray crystallography and structural modeling Because the AR remains the driving force in the progression of more aggressive castration-resistant prostate cancers 139 , it is important to understand how each genetic aberration affects the pharmacology of the AR and its ligands

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glutathione reductase (GR) then reduces GSSG back to GSH using NADPH, sustaining the cellular reducing environment (GSSG + NADPH + H+ 2 GSH + NADP+)

melanogaster involves autonomic, sensory, and motor systems and can be affected by the SNCA gene expression