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8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis
The ARE4 is also the site of TGF-1 action in type II alveolar cells, as TGF-1 induced the binding of Fra-1/c-Jun dimer to the internal AP-1 sequence of the ARE4 site that led to suppression of GCLC transcriptional activity [72]
If a threshold is reached that has been defined in the study protocol, the process stops
