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It is critical to distinguish this ROSImmune Mismatch framework from the established Dual-Role or Janus-faced hypotheses [147, 203]
In addition, while MYCN -amplified NB tumors have increased expression of both system Xc-components compared to MYCN wild-type tumors (SLC7A11 and SLC3A2)
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Possible heterogeneity may also mean that one single biological measure may not be feasible as a marker for ME/CFS
