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The regorafenib investigational arm was concurrently and adaptively randomized against other investigational arms, and regorafenib was ultimately dropped after interim analysis showed a low probability of sufficient improvement in OS as compared with randomized controls

Macroscopic remodeling of the ONH tends to be observed months (rodents) or years (primates) after the onset of ocular hypertension, time lags when it tends to be too late for neuroprotective intervention

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We express our gratitude to students, collaborators, and fellow scientists who shared their scientific interests with us and obtained the findings we have reviewed in this article
