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Description
This dose in rats resulted in an exposure approximately 44-times the human exposure at the RHD, based on AUC
An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1
Through several mechanisms, including direct interaction with SUR1 and membrane depolarization, intracellular calcium mobilization, and insulin granule priming modification, EPAC2 activation may promote the exocytosis of insulin granules [55, 56]
201Y-GAL4/UAS-mito-roGFP2-Grx1
