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However, its efficacy appears to be relatively limited in conditions such as ALS, ataxia, attention deficit hyperactivity disorder (ADHD), depression, chronic fatigue syndrome (CFS), Down syndrome (DS), and sciatica

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The interaction of GR with GRE causes additional conformational changes to take place in the receptor which facilitates the recruitment of, and interaction with, transcriptional coregulators that assist the transcriptional regulatory actions of the GR