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AOD-9604 works through beta-3 receptors, and areas rich in alpha-2 receptors may be relatively resistant to its effects

For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262

[DOI] [PubMed] [Google Scholar] 101.Mohrin, M
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