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Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1

DNA damaging chemotherapies have been used in clinical cancer chemotherapy for decades, and include drugs that induce covalent crosslinks between DNA bases, drugs that attach alkyl groups to bases, and drugs that cause single-strand breaks or DSBs by targeting topoisomerase (Topo) I or II enzymes 83

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Targeted pretend play training in which therapists model and scaffold increasingly complex pretend play scenarios helps children develop the symbolic thinking that underpins language, social interaction, and creativity