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Description
The study showed that 4-OI can lower inflammation and OS by starting the Nrf2 signaling pathway and breaking up the KEAP1-Nrf2 complex
Cys = cysteine
Patients with SLC6A8 deficiencies exhibit intellectual impairment, epilepsy, autism spectrum disorder, and severe language delay
All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction
