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structurally, they are both closely related, both potentiate IGF action and are up-regulated by GH

Spirulina is not a good source of B12 and only contains B12 analogues Because vitamin B12 is water-soluble it's extremely hard to overdose, and because the body is quite inefficient at absorbing B12, supplements often contain 10,000% RDA, sometimes even 100,000% RDA, to try and ensure the body actually absorbs some of it

Cost differs between the two forms

Despite the small size of the tri- and tetrapeptides, a property ultimately necessary for BBB permeability, these molecules were metabolically unstable and likely too hydrophilic to breach the BBB