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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC

doi: 10.1371/journal.ppat.1002093 [DOI] [PMC free article] [PubMed] [Google Scholar] [23].Nair A, Sarma SJ