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Massaging helps the cream to be absorbed better and can stimulate blood circulation, which may enhance the whitening effect
In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients

doi: 10.1016/j.spen.2013.09.002

The optimal dosage for B12 injections depends on different factors
