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doi:10.1530/rep-22-0049

10.1194/jlr.M051755

Effect of riboflavin status on lipid peroxidation Animal studies The results of several animal studies indicate not only the adverse effects of riboflavin deficiency on lipid peroxidation but also the desirable effects of riboflavin administration on it ( Reference Taniguchi and Hara 22 , Reference Liang, Liu and Xu 23 , Reference Bates 27 Reference Rao and Bhat 29 , Reference Wang, Li and Lu 32 , Reference Hirano, Hamajima and Horiuchi 34 , Reference Levin, Cogan and Levy 40 Reference Yagi, Komur and Yoshino 42 )

GPX4 Inhibitors Induce Ferroptosis Other ferroptosis inducers directly target glutathione peroxidase 4 (GPX4), a lipid repair enzyme downstream of GSH that works to limit lipid peroxide accumulation ( Figure 3 )