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Some conditions that are especially benefited by increasing NAD+ levels are: See list of conditions benefitted by NAD+ Substance Abuse Depression Addiction Chronic Pain Sleep Disorders Brain Injury Autism Mitochondrial Disease Lyme Disease Chronic Fatigue Improving Physical Performance in Athletics Anxiety Neurodegeneration You will notice that many of the conditions mentioned involve suboptimal functioning of the brain and nervous system

doi: 10.1378/chest.100.5.1397

Peptides exert their effects throughout the body by interacting with specific receptors on cells and tissues, influencing a wide array of physiological processes

72 Within GABAergic neurons, glutamate produced via PAG undergoes conversion to GABA catalyzed by the enzyme glutamic acid decarboxylase