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Silymarin and Inflammation: Food for Thoughts

Glutathione peroxidase 4 (GPX4) as a selenoperoxidase is a key upstream regulator of ferroptosis which plays two simultaneous roles, one in converting reduced GSH to glutathione disulfide (GSSG) and the other is to inhibit ferroptosis by reducing phospholipid hydroperoxides (PLOOHs) to the corresponding alcohols (PLOHs), thereby preventing the accumulation of lipid peroxides (Jiang et al., 2021)

Smith DM, Aggarwal G, Niehoff ML, Jones SA, Banerjee S, Farr SA, Nguyen AD

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (vcam-1) deficient mice