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The intravenous mode of delivery is intrusive and causes the patient inconvenience, increased medical expenses, and therapeutic side effects (like central venous catheter issues) when receiving extended care

[DOI] [PubMed] [Google Scholar] 82.Shi Q., Liu S., Fonseca V.A., Thethi T.K., Shi L

Setti G, Pezzi ME, Viani MV, Pertinhez TA, Cassi D, Magnoni C, Bellini P, Musolino A, Vescovi P, Meleti M (2020) Salivary microrna for diagnosis of cancer and systemic diseases: a systematic review

This results in the accumulation of cytosolic Ca 2+ followed by activation of synaptic vesicle exocytosis, and release of neurotransmitters