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As suggested before, GULO is likely only involved in the last step of the VC synthesis [13]

For prevention of contrast-induced acute kidney injury, a meta-analysis found misleading beneficial associations that were lost when analysis was restricted to larger studies (52) , and mechanistic studies showed that oral NAC is poorly absorbed with no renoprotective effects (53)

doi: 10.1016/j.pestbp.2023.105341 236 LiJ.et al

Camouflaging nanoparticles with brain metastatic tumor cell membranes: a new strategy to traverse bloodbrain barrier for imaging and therapy of brain tumors
