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TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide present in almost all human and animal cells

This ascertains an essential process not hampered with the initial tendon healing process as similar to fracture healing [83], nor ossicles formation in other tissues as it is with the application of the bone morphogenetic proteins (BMPs) [84,85,86]

The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

It appears to stimulate the growth of new blood vessels (angiogenesis), which is crucial for tissue repair as it increases blood flow to injured areas