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MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome

10.3892/ol.2015.2946 Oncol

However, in cancer cells, dysregulation of the PI3K/AKT/mTOR pathway drives reprogramming of lipid metabolism, which is manifested by abnormal enhancement of FAO, which not only provides ATP for tumors, but also inhibits apoptosis and regulates redox homeostasis, which ultimately leads to the development of tumor drug resistance [36, 188, 189]
