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Gradual disturbances of the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF in alzheimer spectrum

During the period before supplementation, a higher intake of choline plus betaine was associated with lower concentrations of both fasting tHcy and post-Met-load tHcy, but this association was no longer present in the period after fortification (51)

These findings suggest potential for personalized nutrition strategies based on individual metabolomic responses to specific bioactive compounds