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J Physiol Pharmacol 60(Suppl 7):191196 Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y et al (2015) Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

In controlled human trials, doses between 6mg and 12mg per day have reduced markers of oxidative stress, such as malondialdehyde (MDA), and increased antioxidant enzyme activity, including superoxide dismutase (SOD) and glutathione peroxidase (GPx).22 A 2022 meta-analysis combining results from 12 clinical studies also found small but significant reductions in C-reactive protein and interleukin-6 both indicators of systemic inflammation.23 Researchers think this might be due to astaxanthins ability to interact with key inflammatory signaling pathways like NF-B and Nrf2, which help regulate the bodys balance between inflammation and antioxidant defenses.24 25 These effects appear modest but consistent across studies, though its not yet clear how much they translate into real-world health outcomes

with exception of MYO1E, a myosin we detected to be more abundant in tumor (Supplementary Data 2) and which was recently proposed as an independent marker of mortality in lung cancer 25

The preparation of Tregs for therapeutic use faces challenges like efficient isolation, expansion, and maintaining function and stability