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Generally, the frequency differs from person to person and is decided by the doctor
Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y
134 ChenRNishimuraMCKharbandaSPealeFDengYDaemenAet al
Zhang ZJ, Reynolds GP
