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The composition of the BCG cell wall is highly immunogenic (8) due to the large amount of Toll-like receptor 2 (TLR2) ligands, such as lipomannan (9), dimannoside (PIM 2 ) and hexamannoside (PIM 6 ) phosphatidylinositol mannosides (10), as well as muramyl dipeptide derivatives which can also activate TLR4 (11) or nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (12)

Expression increases under conditions of iron excess and inflammation and decreases under hypoxia or conditions of iron demand such as increased erythropoietic activity

To date, research on the role of the EG in S-AKI has mostly been performed in cells or animals, and there have been very few clinical studies

Neuropsychopharmacology 41, 29322940