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People with S1 compression often notice they cannot push off with their toes when walking, or they struggle to rise onto tiptoes on the affected side

Your healthcare provider will monitor you, especially with the first dose

This is associated with a disorder of purine base synthesis, which impairs the metabolism of nucleic acids, and disorders of myelin synthesis, which result in damage and subsequent atrophy of nerve fibers

10.1681/ASN.2011010026 21 DegryseA