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Description
However, a recent Cochrane review of randomized controlled trials found that citicoline had no benefit to acute ischemic stroke patients compared to placebo with respect to all-cause mortality (8 trials)

Furthermore, immunofluorescence studies showed that chronic administration of the drugs tested also decreased levels of GFAP, Caspase-3, and BAX in the CA1 and DG of the hippocampus

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Fiedorowicz JG, Swartz KL
