elevated intracellular glutathione Human cancer-associated fibroblasts enhance levels and antagonize drug-induced prostate cancer cell death Redox State of Glutathione and

3-Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme involved in serine synthesis

A prominent example is EZH2, which is significantly overexpressed in several cancer types, including prostate cancer [150]

When these electrons are transferred through the mitochondrial electron transport chain via oxidative phosphorylation, they yield approximately 2 to 3 ATP per electron pair

Although the axons remain functional and oligodendrocytes remain active in 12-month-old mice, neuronal viability will likely decline due to reduced ATP and increased production of free radicals, perhaps resulting in degeneration with increasing age (Stahon et al., 2016)