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Since intracellular cysteine is a rate-limiting precursor for GSH synthesis, the intracellular GSH level is regulated by the system x c activity

Figure 10 7 Limitations and future directions of ferroptosis in neurodegenerative diseases Although mounting evidence highlights the critical role of ferroptosis in the onset and progression of neurodegenerative diseases, and its status as a novel mode of cell death is increasingly recognized, the field remains at an early stage of conceptual integration and mechanistic exploration

Three major MAPKs are c-JUN N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK)