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However, only 30% of ascorbic acid in chitosan nanoparticles was released in a simulated gastric solution, while the release in simulated intestinal condition exceeded 75% [16]

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In conclusion, curcumin exhibits protective effects against drug-induced toxicity in the male reproductive system through its antioxidant properties, scavenging free radicals, enhancing antioxidant enzyme activity, reducing lipid peroxidation, regulating inflammatory pathways, modulating apoptosis, and preserving hormonal balance and sperm quality, making it a promising therapeutic agent for maintaining male fertility