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Cell 135 , 12011212 (2008)

(LEA / EHMC) 50:12 Replacement dose vs PED 55:47 Four takeaways 57:46 Episode 4 preview and book pre-order What we cover: How body fat suppresses testosterone at two different points in the HPG axis, and why the loop is self-reinforcing The leptin and Kisspeptin pathway most clinics never address Marks case: a 45-year-old with a 240 ng/dL afternoon draw, no workup, and an immediate prescription Primary versus secondary causes, and why Klinefelter syndrome is the under-recognized one to not miss Weight loss dose-response: how much testosterone climbs on lifestyle alone, with GLP-1 agonists, and after bariatric surgery T4DM: why adding testosterone to a structured weight-loss program produced no extra quality-of-life benefit over placebo One week of sleep restriction drops testosterone by about 15 percent in healthy young men

Absorption: Extended-release (ER) stimulants may sometimes kick in later or feel weaker if stomach emptying is delayed

K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts