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Description
Minocycline Minocycline, a tetracycline antibiotic, can penetrate the BBB, inhibit the M1-type (pro-inflammatory) polarization of microglia, and attenuate the microglial expression and release of pro-inflammatory factors such as IL-1, IL-18, and TNF- [152,153,154]
The FIC of the combined drug was determined
It remains a research chemical, and its use in humans is primarily limited to clinical studies, though it is not universally banned
Thus, the NLRP3 inflammasome serves as a key mechanistic link between the initial toxic insult and the ensuing inflammatory response in APAP hepatotoxicity
