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Daran-Lapujade et al, 2007

DSIP for Neuroprotection and Withdrawal Management DSIP has also been suggested to potentially interact with the opioid receptors, which may not only mediate the peptides effects on sleep onset and architecture but also have potential benefits in subjects with addiction

These effects were dependent on UBE3As ligase activity and were observed both with and without oncogene expression, indicating an endogenous role for UBE3A in clock regulation

DJ-1 is an oxidative stress sensor that prevents neuronal death induced by oxidative stress and inhibits the aggregation of -synuclein via its chaperone activity