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This is somewhat indeterminate and will depend on each individual, previous reserves, how they are managed, and the efficiency of the enterohepatic circuit

Heparin nanocarrier loaded with cisplatin and Olaparib downregulates MRP-2 and P-gp resulting in intracellular accumulation of cisplatin and Olaparib causing downregulation of PI3K/AKT/mTOR signaling pathway which enhances the anti-proliferation of cisplatin against CR OC [61]

[DOI] [PubMed] [Google Scholar] 65.Knezevic M., Gojkovic S., Krezic I., Zizek H., Malekinusic D., Vrdoljak B., Knezevic T., Vranes H., Drmic D., Staroveski M., et al

doi: 10.3389/fphys.2023.1287090 Received 05 September 2023 Accepted 30 October 2023 Published 17 November 2023 Volume 14 - 2023 Edited by Fernando Ariel Genta, Oswaldo Cruz Foundation (Fiocruz), Brazil Reviewed by Jan Perner, Biology Centre of the Czech Academy of Sciences, Czechia Rajnikant Dixit, National Institute of Malaria Research (ICMR), India Updates Copyright 2023 Moraes, Martins, Lopes, Martins, Arcanjo, Nascimento, Konnai, da Silva Vaz and Logullo