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extracted and isolated rat chondrocytes and administered sodium nitroprusside dehydrate (SNP), producing NO and therefore promoting apoptosis

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Hyperactivation of the PI3KAKTmTOR pathway could also result in an imbalance between nuclear-encoded and mitochondrial-encoded subunits of the respiratory complexes, as observed for MYC, leading to the production of misassembled complexes, loss of supercomplexes and increased ROS production through Mechanism B