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Cytoskeletal contraction and collapse: Abnormal cross-linking of the actin network causes cytoskeletal contraction and detachment from the plasma membrane, ultimately disrupting cellular morphology and structural integrity, triggering rapid cell death

In an experimental context, this combination allows pathways related to tissue response, cellular communication, structural organization, and extracellular matrix modulation to be observed simultaneously

Abstract Cerebral ischemia-reperfusion (I/R) injury is a major contributor to mortality and long-term disability worldwide, primarily due to excessive reactive oxygen species (ROS) generation after blood flow is restored

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