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Using the ZSF1 rat model our results demonstrate that changes in the microbiome occur at an early timepoint in HFpEF progression, before cardiac function is distinctively impaired [8]

Conclusions and future directions MiR-26 decreases atherosclerosis development in vivo by suppressing the expression of multiple genes, including ACC1, ACC2, ACLY, ACSL3, ACSL4, ALDH3A2, ALPL, BMP2, CD36, COL1A1, CPT1A, CTGF, DGAT2, EHHADH, FAS, FBP1, GATA4, GSK3, G6PC, Gys2, HMGA1, HMGB1, LDLR, LIPC, IL-1, IL-6, JAG2, KCNJ2, MALT1, -MHC, NF-B, PCK1, PLC1, PYGL, RUNX2, SCD1, SMAD1, SMAD4, SMAD5, SMAD7, SREBF1, TAB3, TAK1, TCF7L2, and TNF-

Diabetes Prevention Program Research Group Impact of lifestyle intervention and metformin on health-related quality of life: the Diabetes Prevention Program randomized trial J Gen Intern Med 27 12: 1594-601

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