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Second, GCH1 upregulated levels of CoQ10 and inhibited ferroptosis [36, 37]

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Lipids in Health and Disease, 16(1), 203

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Biogerontology 26 , 111 (2025)

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Notably, the inherent susceptibility of pancreatic -cells to ferroptosis provides a mechanistic basis for DM progression, while hyperglycemia reciprocally promotes systemic iron accumulation, thereby establishing a self-reinforcing cycle

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