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By the sixth decade of life, GH secretion is typically 50 to 70 percent lower than it was in young adulthood, and the downstream effects include reduced muscle mass, increased visceral adiposity, diminished bone density, and impaired recovery from physical stress [13]

MSD PK data was further analyzed in order to identify privileged functional groups that are observed in increased propensity in low in vivo CL u ( in vivo CL u values that are less than mean minus two standard deviations) and long half-life (rat t half_eff greater than 2 h) compounds with low extraction ratios

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