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Biological properties of plasma extracts with non-suppressible insulin-like activity

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Previous studies showed that both experimentally induced circulating IGF-1 deficiency [14] and cell-specific disruption of IGF1R signaling in astrocytes [42] impair astrocyte-mediated NVC responses

Crucially, these processes are limited to adipose tissue by AOD-9604s selective mechanism, protecting muscle cells from metabolic disturbance (4)
