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Glutamine metabolism and supplementation in cancer has also raised many concerns among the scientific community, and deserve some comments
In a series of studies, it was shown that the activity of an isoform of pyruvate kinase (PKM2), the enzyme that catalyzes the final step in glycolysis, can regulate the flow of glucose into serine metabolism 94,97
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SLC38A1 (System A transporter): In liver and metabolic tissues the sodium-dependent transporter selectively imports glutamine to maintain cellular amino acid levels
