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Description
This model is based on the hypothesis that the transition of DNA methylation state of a CpG over a single cell cycle happens in three steps: 1) DNA is passively demethylated through replication, 2) DNA methylation transitions are mediated by TETs and DNMTs, and 3) DNA methylation transition combination states are merged from both homologous chromosomes

Footnotes AUTHOR CONTRIBUTIONS All authors contributed to the study concept & design, data acquisition & analysis, and to drafting manuscript & figures

Fontana et al., 1997b

placebo or control on mortality, ventricular arrhythmias (VAs), angina, heart failure, and reinfarction [6]
