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This scrambling, called disulfide exchange, produces misfolded peptides that do not function properly

We used mice from a somatic transgenic model of MYCdriven liver tumorigenesis 28, which also have elevated MYC and depleted GCLC protein expression (Fig EV3A)

Groups of cultured cells were pretreated with TGF-1 (10ng/ml) for one hour except for the control group, followed by treatment with PFD (standard) and VCN at a concentration (100 g/ml) based on the results obtained from the viability/cytotoxicity analysis by MTT

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