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Concurrently, the activity of ACSL4 (acyl-CoA synthetase long-chain family member 4), a driver of ferroptosis, is increased, promoting fatty acid metabolism and exacerbating lipid oxidation in cell membranes (Tang D
3 = 6 foci
In summary, endothelial cells ferroptosis plays an important role in promoting atherosclerosis, and inhibition of ferroptosis by improving antioxidant metabolism may be a new target for protecting atherosclerosis
