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Importantly, it was established that Klotho is involved in type 2 diabetes and insulin resistance
Lancet 379 , 15911601 (2012)

While no direct epigenetic regulator of DAT endocytosis has been identified, DNA methyltransferases can indirectly affect this process by altering the expression of genes involved in key signaling pathways, such as protein kinase C and D2 receptor systems (Su and Liu, 2017)

If irritation, redness, swelling, or discomfort occurs, discontinue use immediately and consult a healthcare professional