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That means that even though the body is generally able to produce it under normal circumstances, in cases of physical stress such as heavy exercise, injury, or illness we need to take it in from food or supplements

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Among the selected pac-lipids, the NTD interacted mainly with cholesterol and sphingosine (Fig 5), in accordance with previous results in the mammalian NPC system (56), whereas NPC2 crosslinked with similar intensity with all tested ligands (Fig S4), suggesting a broader lipid binding function